Video impression Pioneer2Policymaker Conference ‘Business Opportunities’
In the last decade, major steps have been taken to advance the in vitro field towards more human-relevant models: breakthrough technologies include organoids and organ-on-chips. The session zoomed in on four promising models: intestinal/airway organoids (Jeffrey Beekman, UMC Utrecht). The second one was bio-printed liver (Bart Spee, Utrecht University). Third: the Polycystic Kidney Disease array Bange, and fourth: precision-cut tissue slices (Mitchel Ruigrok, Medical Innovation Xccelerator, start-up from Groningen). After these models were pitched, session participants discussed how to further develop these models so that they might fulfill their potential: to improve testing of chemical and pharmaceutical compounds and replace current animal tests that are often known to be poorly predictive for effects in humans. As promising as these technologies are, there still exists a developmental gap between an early concept and a mature, fully validated model ready to be implemented. This so-called valley of death needs to be bridged.
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